The Interactive Effect of Prepregnancy Overweight/Obesity and Isolated Maternal Hypothyroxinemia on Macrosomia

Abstract Context Prepregnancy overweight/obesity (OWO) and isolated maternal hypothyroxinemia (IMH) may increase the risk of macrosomia, but little is known about their potential combined effect on macrosomia. Objective The aim this study was to assess whether prepregnancy OWO first-trimester IMH have a synergistic Methods A large prospective cohort in Chinese population from January 2016 December 2018 tertiary care center. In total, 34 930 pregnant women were included. main outcome measure Results total participants comprising euthyroid cases included study. independently associated with an increased macrosomia (adjusted odds ratio [OR] 2.48, 95% CI 2.22, 2.78, adjusted OR 1.65, 1.34, 2.01, respectively). coexistence 5.26 (95% 3.9, 7.0) compared without either condition. additive interaction between found be significant regard Conclusion first trimester synergistically